Bach Pharma is dedicated to ongoing research on the efficacy of our treatments for neurodegenerative disease. Because of the ongoing dedication of our management, medical and executive teams, Bach Pharma continues to find new and different potential applications for GVT and our research.
Bach Pharma, working with Salvim LLC, has positive research supporting GVT's effects on the COVID-19 virus and its complications. Current research in Russia has shown that GVT's anti-inflammatory properties can repress the Cytokine Storm and allow the normalization of the body's immune system.
Read the Bach Pharma/Salvim joint report here.
Dr. Ashok Shetty recently published new research in Redox Biology that shows the effectiveness of Bach Pharma's GVT (Monosodium Luminol) in the fight against Gulf War Illness. He states that GVT "reinstates redox homeostasis, improves cognition, mood and neurogenesis, and alleviates neuro and systemic inflammation in a model of Gulf War Illness."
Read Dr. Shetty's report here.
Bach is dedicated to developing drugs that modulate fundamental pathways regulating redox status and oxidative injury, thus normalizing the cellular redox environment and suppressing cell dysfunction and death. GVT, the lead compound, is distinct from classic "antioxidant" strategies by its ability to recycle itself, changing toxic reactive oxygen species into light, and to protect mitochondria and cross the blood-brain barrier. These properties should enable GVT to effectively address untreatable, fatal neurodegenerative disorders.
Oxidative stress occurs in cells when production of reactive oxygen species, for example in pathologically activated inflammatory processes, exceeds the level of protective cellular antioxidant enzymes. The result is oxidative injury to cellular macromolecules and, especially, to the mitochondria. Such damage is implicated in numerous serious diseases or environmental toxicities, targeting a variety of organ systems. These diseases include fatal, poorly addressed neurodegenerative disorders such as ALS, Alzheimer’s and Parkinson's diseases, Friedreich's ataxia and ataxia-telangectasia.
In preclinical studies, GVT was protective in several animal models for neurodegenerative disorders, involving mitochondrial injury, neuronal death and motor neuron dysfunction. GVT treatment attenuated mitochondrial dysfunction and cell death, normalized motor neuron function and prolonged survival. GVT is orally bioavailable, crosses the blood/brain barrier and normalizes gene expression in the brain, affecting key pathways induced in oxidative injury. Based on its compelling, multifunctional mechanism of action, GVT acts in a neuroprotective fashion, preserving neurons. In comparison, currently approved treatments are focused, instead, on lessening symptoms. Bach plans its first U.S. clinical program, to study neuroprotective effectiveness of GVT in ALS patients.
Click title links to download as a PDFs...
Neuroprotective effects of the drug GVT (monosodium luminol) are mediated by the stabilization of Nrf2 in astrocytes
The drug monosodium luminol (GVT®) preserves thymic epithelial cell cytoarchitecture and allows thymocyte survival in mice infected with the T cell-tropic, cytopathic retrovirus ts1
Retrovirus-Induced Oxidative Stress with Neuroimmunodegeneration Is Suppressed by Antioxidant Treatment with a Refined Monosodium -Luminol (Galavit)
The following book has been published by researchers working with Bach Pharma's products and serving on our scientific advisory report:
Neurodegeneration Theory, Disorders and Treatments
by Alexander S. McNeill, Nova Publications. (2011)